Inorganic arsenic exposure and susceptibility: a systematic evidence map of modifying factors
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There has been a recent uptick in the development of systematic evidence maps (SEM), with the appeal being the ability to systematically identify and categorize chemical-specific literature that may be potentially relevant to human health risk assessment. Inorganic arsenic (iAs) is a naturally occurring element widely distributed throughout the Earth’s crust. In addition to natural sources, industrial activities such as coal combustion and smelting operations can release iAs into air and water. iAs exposure has been associated with cancer and noncancer human health outcomes in epidemiologic studies, and there are ample epidemiological studies exploring intrinsic and extrinsic factors that influence susceptibility to iAs. Using iAs as an example, the objective of this study is to explore the use and feasibility of the SEM approach to provide a clearer picture of the available literature on modifying factors that may impact the relationship between chemical exposure and outcome.