Associations between Disinfection Byproducts and Birth Defects: Use of Relative Potency Factors
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Component methods often are used to assess risks from chemicals in the environment, such as dose addition which assumes that the chemicals in a mixture are toxicologically similar and cause a common adverse health effect. Dose additivity serves as the basis for mixture methods including the relative potency factor (RPF) method used here to compare weighted (using BMD data) versus unweighted effects estimates for birth defects in relation to DBPs.