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Emerging Per- and Polyfluoroalkyl Substances in Tap Water from the American Healthy Homes Survey II

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  Humans experience widespread exposure to anthropogenic per- and polyfluoroalkyl substances (PFAS) through various media, which can lead to a wide range of negative health impacts. Tap water is an important source of exposure in communities with any degree of contamination but routine or large-scale PFAS monitoring often depends on targeted analytical methods limited to measuring specific PFAS. We analyzed 680 tap water samples from the American Healthy Homes Survey II for PFAS using non-targeted analysis (NTA) to expand the range of detectable PFAS. Based on detection frequency and relative abundance, about half of the identified PFAS were found only by NTA. We identified (with varying degrees of confidence) 75 distinct PFAS, including 57 exclusively detected by NTA. The identified PFAS are members of seven structural subclasses differentiated by their head groups and degree of fluorination. Clustering analysis categorized the PFAS into four coabundance groups dominated by specific PFAS subclasses. One group uniquely identified by NTA contains zwitterionic PFAS and other PFAS transformation products which are likely associated with aqueous firefighting foam contaminants in a small number of spatially correlated samples. These results help further characterize the scope of exposure to emerging PFAS experienced by the U.S. population via tap water and augment nationwide targeted-PFAS monitoring programs.

Impact/Purpose

Tap water is a significant source of exposure in communities with any degree of contamination but PFAS screening commonly relies on limited targeted PFAS panels. We analyzed 680 tap water samples from the American Healthy Homes Survey II for PFAS using a non-targeted analysis (NTA) approach to expand the range of detectable PFAS.

Citation

Boettger, J., N. Deluca, M. Zurek-Ost, K. Miller, C. Fuller, K. Bradham, P. Ashley, W. Friedman, E. Pinzer, D. Cox, G. Dewalt, K. Isaacs, E. Cohen-Hubal, AND J. McCord. Emerging Per- and Polyfluoroalkyl Substances in Tap Water from the American Healthy Homes Survey II. American Chemical Society, Washington, DC, 59(5):2686–2698, (2025). [DOI: 10.1021/acs.est.4c08037]

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  • https://pubmed.ncbi.nlm.nih.gov/39878442/
DOI: Emerging Per- and Polyfluoroalkyl Substances in Tap Water from the American Healthy Homes Survey II
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Last updated on February 13, 2025
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