Role of Transient Receptor Potential M3 (TRPM3) in the cardiopulmonary response of mice to extreme heat

This work describes the impact of extreme heat exposure on the cardiopulmonary response of mice and the role of transient receptor potential M3 (TRPM3) cation channel. 

Impact/Purpose

This work describes the effects of extreme heat on health and well-being. Specifically, it shows that heat causes acute cardiovascular and ventilatory changes that are mediates by a heat sensor called transient receptor potential M3 channel. These data provide biological plausibility to extreme heat-related effects. 

Citation

Vaziri, M., M. Fiamingo, L. Klein, W. Oshiro, P. Evansky, Ian Gilmour, A. Farraj, AND M. Hazari. Role of Transient Receptor Potential M3 (TRPM3) in the cardiopulmonary response of mice to extreme heat. Society of Toxicology, Orlando, FL, March 16 - 20, 2025.