A Roadmap for Efficient Systematic Reviews of Human Exposure Studies
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Several tools and approaches exist for the evaluation of studies containing human exposure data, such as the U.S. EPA Staff Handbook for Developing Integrated Risk Information System (IRIS) Assessments, and Risk of Bias in Non-randomized Studies of Exposures (ROBINS-E). Despite the robustness of these frameworks there is difficulty in applying these toward individual chemicals, because they are chemical-agnostic. A reviewer must have chemical-specific knowledge to effectively use these tools. In this presentation we introduce a roadmap for developing chemical-specific evaluation criteria that can supplement existing study evaluation tools or frameworks.