Application of a read-across framework to support EPA’s Provisional Peer-Reviewed Toxicity Value (PPRTV) Program.
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Within the EPA PPRTV program, read-across is routinely used for screening-level human health assessment of data-poor chemicals found at contaminated sites across the U.S. Analogues are identified and evaluated based on a three major types of similarity (structure, toxicokinetics and toxicodynamics) and a point of departure (POD) is adopted from the single best analogue for quantitative read-across. The methodology for read-across applied to PPRTV assessments has been recently updated, proposing a framework that is informed by practical experience and advances in the fields of read-across and new approach methods (NAMs). This presentation will discuss key advancements of this framework aimed at expanding its application to other risk decision contexts, enhancing expert judgement and increasing transparency and confidence in read-across predictions. Case studies and lessons-learned will be presented, showcasing the evolution of this framework and its current implementation to support the PPRTV program.