Quantification of 40 PFAS in Human Milk from Imprint Cohort
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PFAS are known developmental toxicants with impacts on physiology, growth, and metabolism. This study looks to understand the impacts of prenatal PFOA (80mg/kg daily GD9-21) exposure on bone physiology and glucose metabolism. Intraperitoneal glucose tolerance testing (IPGTT) was used to monitor the glucose response in offspring at two time periods, PND38 – PND40 and at PND 88 – 90. At PND 90, offspring were assessed for impacts on bone density. Micro-computed tomography (Micro CT) measured bone mineral density (BMD) and trabecular mineral density (TMD) in the femur in offspring at necropsy (PND90). PFOA-exposed offspring showed a significantly elevated glucose response compared to control offspring 15 minutes after glucose injection. Bone mineral density was evaluated in cortical and trabecular samples. Prenatal PFOA exposure was associated with significantly decreased cortical bone density in female offspring at PND90. This study aims to assess PFOA's effects on biochemical pathways in glucose regulation and dysfunction in bone formation.