UNCERTAINTIES IN QUANTITATIVE CANCER RISK ASSESSMENT: SOME APPROACHES TO REDUCE THEM

Abstract

There are three major sources of uncertainties in quantitative cancer risk assessment: low-dose extrapolation, route-to-route extrapolation, and species-to-species extrapolation. cientific information and procedures useful for reducing uncertainties are discussed. wo examples, one relating to genotoxic carcinogens and another to promoting agents, are presented to demonstrate the importance of incorporating biologic information into the risk assessment. hese examples also demonstrate that a quantitative risk assessment is a multidisciplined endeavor that involves various branches of the biomedical and mathematic sciences.

Citation

Chen, C. UNCERTAINTIES IN QUANTITATIVE CANCER RISK ASSESSMENT: SOME APPROACHES TO REDUCE THEM. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-89/051 (NTIS PB89221303), 1989.

Additional Information

Presented at the Symposium on Health Risk Assessment, Academia, Academia Sinica, Taipei, Taiwan, 12/20-22/88

• UNCERTAINTIES IN QUANTITATIVE CANCER RISK ASSESSMENT: SOME APPROACHES TO REDUCE THEM