IRIS Toxicological Review and Summary Documents for N-Hexane (External Review Draft)
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Abstract
EPA's assessment of the noncancer health effects and carcinogenic potential of n-hexane was last prepared and added to the IRIS data base in 1990. The IRIS program is updating the IRIS assessment for n-hexane; this update will incorporate health effects information published since the last assessment was prepared as well as new risk assessment methods. The IRIS assessment for n-hexane will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physicochemical and toxicokinetic properties of the chemical and its toxicity in humans and experimental systems. The assessment will present reference values for noncancer effects of n-hexane (RfD and RfC) and a cancer assessment, where supported by available data. The Toxicological Review and IRIS Summary will be subject to internal peer consultation, Agency review, and external scientific peer review.Impact/Purpose
EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for n-hexane. The outcome of this project is an updated Toxicological Review and IRIS Summary for n-Hexane that will be entered into the IRIS database. IRIS is an EPA data base containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment process, i.e., hazard identification and dose-response evaluation. IRIS provides a nationally and internationally used data base of toxicity information that is used in risk assessments, site-specific environmental decisions, and rule making. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risks associated with environmental contaminants.Citation
U.S. EPA. IRIS Toxicological Review and Summary Documents for N-Hexane (External Review Draft). U.S. Environmental Protection Agency, Washington, D.C., EPA/635/R-03/012, 2005.History/Chronology
| Date | Description |
|---|---|
| 02- Feb 2005 | EPA released the external review draft for public review and comment. |
| 02- Mar 2005 | EPA hosted an independent peer review panel workshop to discuss the draft report. |
| 03- Dec 2005 | EPA released the final Toxicological Review and IRIS Summary for n-Hexane. |
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- N-Hexane External Peer Review Charge (PDF) (2 pp, 18.6 KB, about PDF)
- N-Hexane External Peer Review Charge Toxicological Review (PDF) (162 pp, 4.3 MB, about PDF)
- N-Hexane External Peer Review Charge IRIS Summary (PDF) (28 pp, 175.8 KB, about PDF)